Kroungold Analytical Inc.

Providers of the finest
in two-dimensional chromatography (2DLC) software, software services for laboratory
automation and separation science, and systems integration.
What do we do?
We believe that two-dimensional chromatograhy
can be simply implemented in an "add on" approach.
We sell the software and hardware
that lets you configure a normal one-dimensional chromatograph into a two-dimensional
instrument. You add a pump, a column, a valve and some other components plus
our software and hardware interface. Our product works with detectors from one-channel
detectors such as the evaporative light scattering detector (ELSD) to multi-channel
detectors such as mass spectrometers and diode array detectors (DAD's). Our
product has been used for over 4 years with stunning results with applications
from polymer analysis to proteomics and metabolomics.
The time for routine usage of two-dimensional
separations by liquid chromatography is long overdue.
Background
Due to selectivity limitations inherent
in any single-column separation technique, complex sample fractionation often
requires more than one column or separation axis for single component resolution.
Multidimensional liquid chromatography is a powerful technique which when run
in the so-called "comprehensive" mode can provide far more zone resolution
than single column techniques.
Specifically two-dimensional liquid chromatography
can be easily implemented with a few additional pieces of chromatographic equipment.
Further information about this exciting technique can be found in the link above
to a recent book on multidimensional LC.
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